
Stocks slipped after a session dominated by an intense obesity drug takeover fight and stronger than expected tech earnings. The S&P 500 finished down 1.0 percent as investors repriced risky M&A bets and digested big cloud and retail results. In the short term the market reacted to deal headlines and an uneven slate of corporate updates. Over the longer term the developments matter because they shape competition in a large new pharmaceutical market and set revenue baselines for major technology platforms across the next year. The story has global reach. U.S. investors watched Pfizer and Eli Lilly moves closely. European and Asian markets tracked cross-border M&A pressure on Novo Nordisk. Emerging market exporters will watch pricing and demand for consumer goods. Compared with recent months the session showed faster re-rating on headline news and heavier profit taking in newly listed stocks, which is consistent with the pullback that followed several big IPOs earlier this year.
Market snapshot and key movers
The S&P 500 closed down 1.0 percent. Several names set the tone. Travel technology newcomer Navan saw its shares slump about 20 percent on its trading debut after the company and early investors raised $923 million in the IPO. Navan closed the day at $20, below the IPO price of $25. The pullback in newly public stocks was a major contributor to overall market weakness. Meanwhile big cap earnings lifted pockets of the market. Amazon (NASDAQ:AMZN) jumped in extended trading after reporting stronger revenue driven by cloud demand and resilient North American sales. Apple (NASDAQ:AAPL) posted improving iPhone volumes and raised near term growth expectations. The session mixed deal risk with earnings outperformance.
Investor focus tightened on message risk around M&A and pricing. Companies with direct exposure to the obesity drug market or heavy AI and cloud investment attracted the most attention. The short term reaction penalized riskier public entries and rewarded large-cap tech platforms that met or beat operational targets. Longer term the market is setting fresh valuation anchors for cloud revenue growth and for pharma companies that can expand market share in new therapeutic categories.
Obesity drug showdown reshapes M&A calculus
Eli Lilly (NYSE:LLY) reported a quarterly revenue surge as sales of diabetes drug Mounjaro and obesity treatment Zepbound exceeded expectations. The company raised its 2025 revenue guidance after revenue jumped 54 percent to $17.6 billion year over year. That came even as realized prices fell roughly 10 percent because of pricing pressures. Lilly shares rose on the report as investors priced accelerating top line momentum.
At the same time Novo Nordisk (NYSE:NVO) launched an unsolicited bid worth up to $9 billion for obesity biotech Metsera. That offer opened a crossfire with Pfizer (NYSE:PFE), which had previously agreed to buy Metsera for up to $7.3 billion. Pfizer called the rival bid reckless and signaled plans to contest it in court. Metsera described Novo’s proposal as superior and gave Pfizer a short window to respond. The deal fight matters now because the obesity market could reach very large scale by decade end and because consolidation accelerates access to promising clinical pipelines and regulatory expertise. Analysts flagged potential regulatory friction for a Denmark based bidder pursuing a U.S. target, which raises timing and approval uncertainty.
The net effect on equities was clear. Lilly outperformed in the session while Novo shares weakened. The balance between M&A premiums and regulatory scrutiny will determine the near term pricing of companies that compete in the obesity and diabetes segments. For investors the contest highlights how fast therapeutic markets can reshape corporate strategies and valuations once a clear commercial leader emerges.
Big tech delivers cloud and U.S. resiliency
Amazon (NASDAQ:AMZN) reported total sales of $180.2 billion, up 13 percent year over year. North American sales rose 11 percent to $106.3 billion. The cloud division, Amazon Web Services, grew 20 percent to $33 billion. AWS saw its fastest growth rate since 2022. The results underlined how investments in faster fulfillment and AI related services are now translating into revenue acceleration.
Investors rewarded the strongest cloud and U.S. sales beats. The improvement sets a higher baseline for what the market will expect from large cloud platforms in coming quarters. It also raises the bar for smaller cloud players that need to show differentiated workloads or lower cost structures to compete. The Amazon print fed a wider technology narrative. Firms that can show sustained cloud growth without excessive margin dilution captured the most investor interest in the session.
Consumer signals and seasonal pressure
Consumer facing names offered mixed signals. Hershey (NYSE:HSY) warned of weaker Halloween candy volumes even as dollar sales may rise because of higher prices. S&P Global data show candy prices up more than 10 percent year over year, driven by higher cocoa costs. Hershey noted that calendar timing and weather likely compressed purchases into the last week before Halloween. The message warns retailers and suppliers that higher prices can blunt volume and alter seasonal cadence.
Other consumer names that underperformed included Chipotle (NYSE:CMG), which recorded falling foot traffic among younger adults, and BYD (OTC:BYDDF), where profit and revenue declined as a price war pressured EV makers in China. The consumer tone was uneven and suggests spending is shifting between discretionary categories depending on price and timing.
Market implications and what to watch next
The session emphasized two cross market themes. First, headline M&A can move entire sectors when the target plays into a major growth market. The obesity drug bids provide a live example of how deal premiums and regulatory questions interact to drive share price moves. Second, cloud revenue that accelerates without margin collapse still commands investor support. Amazon’s print reinforced that case and set expectations for peers with heavy AI and fulfillment investments.
In the next days market participants will watch court filings and regulatory commentary tied to the Metsera offers. They will also study upcoming earnings for additional confirmation that cloud gains will persist beyond a single quarter. Finally, newly listed names will remain vulnerable to re pricing if liquidity conditions tighten or if growth guidance falls short of optimistic early valuations.
Overall the trading session delivered a clear message. Deal activity and tech execution matter now. They will shape sector returns in the near term and help define competitive positions for the coming years. Observers should track deal outcomes, cloud growth rates and consumer volume trends to understand where pressure or opportunity is likely to concentrate in the weeks ahead.








